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目的 :探讨IL - 4、IL - 10水平变化在甲亢的临床意义。方法 :选择甲亢未治疗组 6 4例、甲亢经1 31 I治疗组 39例和正常对照组 35例 ,用化学发光法测定FT3、FT4 、TSH的含量 ,用放射免疫分析测定IL - 4、IL - 10含量。结果 :甲亢未治疗组患者血清IL - 4、IL - 10水平均高于正常对照组 (p <0 0 1、p <0 0 5 )。1 31 I治疗组患者血清IL - 4、IL - 10水平均低于未治疗组 (p <0 0 1、p <0 0 5 )。甲亢1 31 I治疗组患者血清IL - 4、IL - 10与正常对照组差异无显著性 (p>0 0 5 )。结论 :IL - 4、IL - 10在甲亢的发病机理中起重要作用 ,判断疗效有一定意义。
Objective: To investigate the clinical significance of IL - 4 and IL - 10 levels in hyperthyroidism. Methods: Sixty - four cases of hyperthyroidism untreated group, 39 cases of hyperthyroidism treated by 131 I group and 35 cases of normal control group were selected. The contents of FT3, FT4 and TSH were determined by chemiluminescence method. The levels of IL - 4 and IL - 4 - 10 content. Results: The serum levels of IL - 4 and IL - 10 in hyperthyroidism untreated group were higher than those in normal control group (p <0.01, p <0.05). The serum levels of IL - 4 and IL - 10 in the 131 I treatment group were significantly lower than those in the untreated group (p <0.01, p <0.05). The serum levels of IL - 4 and IL - 10 in hyperthyroidism patients with 131 I treatment were not significantly different from the controls (p> 0.05). Conclusion: IL - 4 and IL - 10 play an important role in the pathogenesis of hyperthyroidism, and the curative effect is of certain significance.