对150例IgA肾病的肾活检标本进行了光镜及透射电镜的形态学观察,[其组织学改变由轻微病变至弥漫性系膜增殖,根据病变的严重程度作者将其分为6个亚型。系膜基质的增生为其突出的超微结构改变,常显示为局灶节段性、球性系膜细胞增殖和显著的系膜基质的增加。电子致密沉着多见于系膜基质及内皮细胞下,这些沉着物的多少与病变的严重程度未见有肯定的联系。 150 cases of IgA nephropathy renal biopsy specimens were observed by light microscopy and transmission electron microscopy, the histological changes from mild lesions to diffuse mesangial proliferation, according to the severity of the disease the authors will be divided into six subtypes . Mesangial stromal proliferation of its prominent ultrastructural changes, often showed focal segmental, mesangial cell proliferation and significant mesangial matrix increase. Electronically dense deposition more common in mesangial matrix and endothelial cells, the number of these deposits and the severity of the lesion has not been affirmed.