Background Premature ventricular contractions(PVCs) are frequently seen in children. However, there are less systematic and longer following-up studies examining the prognosis of PVCs in children. The aim of this study was to evaluate the medium to long term prognosis of PVCs in childhood and whether there is a differential prognosis in different primary diseases of PVCs. Methods This study reviewed the data of 106 pediatric patients(49F/57 M, 7.5 ± 3.8 years) seen at the Affiliated Hospital of Qingdao University with the diagnosis of PVCs between 1999 and 2005. Data on demographics, clinical presentation, laboratory tests, and e chocardiograms of patients were extracted from the available clinical records. Results A total of 35(33.0%) children presented with PVCs due to myocarditis, 7(6.6%) due to cardiomyopathies, 7(6.6%) due to mitral valve prolapse(MVP), 10(9.4%) due to operation for congenital heart disease(O-CHD), 16(15.2%) due to left ventricular false tendons(LVFT), and 31(29.2%) due to unknown cause. Holter did not show PVCs during follow-up period in 100% of myocarditis patients, 57% of cardiomyopathy patients, 71% of MVP patients, 60% of O-CHD patients, 88% of LVFT patients, 87% of unknown cause patients. The PVCs disappeared in 93% of patients who did not use anti-arrhythmic drugs and in 76% of patients who used antiarrhythmic drugs. There was no a significant difference in prognosis between myocardial nutrition combined with intravenous injection of immunoglobulin(IVIG) group and propafenone group. Conclusions PVCs caused by different primary diseases has a favorable prognosis in children. Usually, the PVCs will reduce even disappear during follow-up. The patients with PVCs due to myocarditis should be preferred use myocardial nutrient combined with IVIG. However, there are less systematic and longer following-up studies examining the prognosis of PVCs in children. The aim of this study was to evaluate the medium to long term prognosis of PVCs in childhood and whether there is a differential prognosis in different primary diseases of PVCs. Methods This study reviewed the data of 106 pediatric patients (49F / 57 M, 7.5 ± 3.8 years) seen at the Affiliated Hospital of Qingdao University with the diagnosis of PVCs between 1999 and 2005. Data on demographics, clinical presentation, laboratory tests, and e chocardiograms of patients were extracted from the available clinical records. Results A total of 35 (33.0%) children presented with PVCs due to myocarditis, 7 (6.6%) due due to mitral valve prolapse (MVP), 10 (9.4%) due to operation for congenital heart disease (O-CHD), 16 (15.2%) due to left ventricular false tendons (LVFT), and 31 (29. 2%) due to unknown cause. Holter did not show PVCs during follow-up period in 100% of myocarditis patients, 57% of cardiomyopathy patients, 71% of MVP patients, 60% of O-CHD patients, 88% of LVFT patients , 87% of unknown cause patients. The PVCs disappeared in 93% of patients who did not use anti-arrhythmic drugs and in 76% of patients who used antiarrhythmic drugs. There was no a significant difference in prognosis between myocardial nutrition combined with intravenous injection Of, the PVCs will reduce even disappear during follow-up. The patients with PVCs due to myocarditis should be the preferred use of metacrine combined with IVIG.