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血清 CK—BB 同功酶活性罕见异常高度(即可以检出的高度)。前列腺疾病患者中,免疫反应性 CK—BB 或 CK—BB 活性升高,曾被推荐作为前列腺腺癌的一种指征。作者报告一例巨大良性前列腺增生,但无临床或病理学的前列腺腺癌证据的老年男性患者,用琼脂糖凝胶电泳发现其血清 CK—BB活性是1u/L(正常=0)。为总 CK 活性的10%。前列腺切除术后1小时,血清 CK—BB 进一步增加到16u/L(总 CK 的20%),而术后第二天即变为不可检出。此发现说明:(1)此例血清 CK—BB 活性起源于增大的前列腺,(2)前列腺疾病男性患者血清 CK—BB 活性异常增高,并不一定指示前列腺腺癌的存在,(3)如果使用那些并非一贯都能使“心脏特异性”的 CK—MB 与 CK—BB 分离的方法检测 CK 同功酶,那末,
Serum CK-BB isoenzyme activity is rare abnormally high (ie, detectable height). Prostate disease in patients with immunoreactive CK-BB or CK-BB activity, has been recommended as an indication of prostate cancer. The authors report an elderly male patient with large benign prostatic hyperplasia but no evidence of clinical or pathological prostate cancer who was found to have serum CK-BB activity of 1 u / L (normal = 0) by agarose gel electrophoresis. 10% of total CK activity. One hour after prostatic resection, serum CK-BB was further increased to 16u / L (20% of total CK) and became undetectable the next day after surgery. This finding suggests that: (1) serum CK-BB activity in this case results from an enlarged prostate, (2) an abnormally elevated serum CK-BB activity in male patients with prostate disease does not necessarily indicate the presence of prostate adenocarcinoma, (3) CK isozymes are detected using methods that do not always separate “heart-specific” CK-MB from CK-BB,