论文部分内容阅读
目的:研究伊曲康唑对双氯芬酸钠在比格犬体内药动学参数的影响。方法:采用随机交叉试验方法,一组口服双氯芬酸钠,另一组同时口服双氯芬酸钠和伊曲康唑,清洗期1周后,两组交叉服用药物。用HPLC法测定比格犬合用伊曲康唑前后双氯芬酸的血药浓度,并对其药动学参数进行分析。结果:较单独给予双氯芬酸钠,合用伊曲康唑使双氯芬酸钠血药浓度曲线下面积(AUC_(0–∞))与最大血药浓度C_(max)分别降低31%和42%。而达峰时间和半衰期并无显著差异(P>0.05)。结论:伊曲康唑可能通过影响双氯芬酸的胃肠道吸收过程,来影响AUC_(0–∞)和C_(max)。
Objective: To study the effect of itraconazole on the pharmacokinetic parameters of diclofenac sodium in beagle dogs. METHODS: A randomized crossover study was conducted in which one group received diclofenac sodium orally and the other group was given diclofenac sodium and itraconazole orally. One week after the washout period, the two groups were given medication crossover. The plasma concentrations of diclofenac before and after itraconazole was given to beagle dogs were determined by HPLC and their pharmacokinetic parameters were analyzed. Results: Compared with diclofenac alone and itraconazole alone, the area under the curve of plasma concentration of diclofenac (AUC_ (0-∞)) and maximal blood concentration (Cmax) decreased by 31% and 42% respectively. The peak time and half-life and no significant difference (P> 0.05). CONCLUSION: Itraconazole may affect the AUC_ (0-∞) and C_max by affecting the gastrointestinal absorption of diclofenac.