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本院14例异基因骨髓移植中发生急性移植物抗宿主病7例(50％),其中Ⅳ级2例(14.3％)。Ⅰ～Ⅱ级5例;慢性移植物抗宿主病2例(14.3％)。9例胎肝移植中1例发生移植物抗宿主病Ⅰ级。1例自体骨髓移植后因输未经照射的异体血引起急性移植物抗宿主病。收集1988年至1991年12月国内文献报告异基因骨髓移植57例,发生急性移植物抗宿主病44例(77.19％),Ⅲ级以上12例(20.05％),慢性移植物抗宿主病14例(24.56％)。初步分析我国移植物抗宿主病的发病率与欧美早期报告近似。本文结合国内外文献报告介绍了移植物抗宿主病的防治措施。
Seven cases (50%) of acute graft versus host disease occurred in 14 allogeneic bone marrow transplantation patients in our hospital, of which 2 cases (14.3%) were grade Ⅳ. Grade Ⅰ ~ Ⅱ 5 cases; chronic graft versus host disease in 2 cases (14.3%). One case of graft-versus-host disease occurred in 9 cases of fetal liver transplantation. One case of autologous bone marrow transplantation caused by non-irradiated allogeneic blood caused by acute graft-versus-host disease. A total of 57 cases of allogeneic bone marrow transplantation were reported from 1988 to December 1991 in our country. There were 44 cases (77.19%) of acute graft versus host disease, 12 cases (20.05%) of grade Ⅲ or above, and 14 cases of chronic graft versus host disease (24.56%). Preliminary analysis of the incidence of graft-versus-host disease in China and the United States early report similar. This article describes the prevention and treatment of graft-versus-host disease combined with domestic and foreign literature reports.