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目的探讨胎盘多肽注射液对肺腺癌患者化疗效果的影响。方法选取2012年4月至2015年4月间湖北省襄阳市中心医院收治的112例肺腺癌患者,采用随机数表法分为观察组和对照组,每组56例。观察组患者在紫杉醇和顺铂(TP)化疗方案基础上联合胎盘多肽注射液治疗,对照组患者采用TP化疗方案治疗,观察两组患者治疗效果、T淋巴细胞亚群水平及不良反应情况。结果治疗前两组患者T细胞亚群水平差异无统计学意义(P>0.05);治疗后观察组患者CD3~+、CD4~+、CD8~+及CD4~+/CD8~+水平均高于对照组,差异有统计学意义(P<0.05)。观察组患者的总有效和不良反应发生率分别为62.5%和16.1%,对照组患者的总有效率和不良反应发生率为48.2%和28.6%,差异均有统计学意义(均P<0.05)。结论胎盘多肽注射液有助于提高肺腺癌患者免疫功能,减轻化疗的不良反应,提高化疗效果,值得临床应用及推广。
Objective To investigate the effect of placental peptide injection on the efficacy of chemotherapy in patients with lung adenocarcinoma. Methods One hundred and twelve patients with lung adenocarcinoma admitted from April 2012 to April 2015 in Xiangyang Central Hospital of Hubei Province were randomly divided into observation group and control group with 56 cases in each group. Patients in the observation group were treated with combination chemotherapy of paclitaxel and cisplatin (TP) and placental peptide injection. Patients in the control group were treated with TP chemotherapy. The therapeutic effect, level of T lymphocyte subsets and adverse reactions in both groups were observed. Results There was no significant difference in T cell subsets between the two groups before treatment (P> 0.05). After treatment, the levels of CD3 +, CD4 +, CD8 + and CD4 + / CD8 + in the observation group were significantly higher than those in the control group Control group, the difference was statistically significant (P <0.05). The total effective rate and adverse reaction rate in the observation group were 62.5% and 16.1% respectively. The total effective rate and adverse reaction rate in the control group were 48.2% and 28.6%, respectively, with significant differences (all P <0.05) . Conclusion Placental peptide injection can help improve the immune function of patients with lung adenocarcinoma, reduce the adverse reactions of chemotherapy and improve the efficacy of chemotherapy, which is worthy of clinical application and promotion.