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目的 研究淮安市烟、酒因素对食管癌的作用。方法 用１：１全人群病例－对照研究的方法调查淮安市５４９ 对食管癌病例和对照。结果 在调整了年龄、文化程度、腌制品、水果等因素后，发现吸烟是淮安市食管癌的危险因素。与不吸烟人群相比，男性现仍吸烟者ＯＲ为２．５（９５％ ＣＩ：１．６～３．８），男性曾经吸烟者ＯＲ为１．９（９５％ ＣＩ：０．９～４．０），男性患食管癌的危险随着吸烟量的增多，吸烟年限的延长而增加，且有显著的剂量反应关系，趋势检验Ｐ＜ ０．０１，女性也表现出相同的危险趋势，但大部分未达显著水平。采用Ｂｒｕｚｚｉ的方法估计淮安市男性吸烟调整的人群归因危险度百分比（ＰＡＲ％ ）为４５．７％ ，女性为８．３％ 。本研究未发现淮安市食管癌与饮酒相联系的证据。结论 吸烟是淮安市食管癌高发的重要原因之一，饮酒因素对淮安市食管癌的作用需进一步研究。
Objective To study the effects of smoke and alcohol factors in Huai’an City on esophageal cancer. Methods A total of 1:1 population-control study was conducted to investigate 549 cases of esophageal cancer and controls in Huai’an City. Results After adjusting for factors such as age, education level, pickled products, and fruits, it was found that smoking was a risk factor for esophageal cancer in Huaian City. Compared with non-smokers, men still smokers have an OR of 2.5 (95% CI: 1.6 to 3.8), and men’s former smokers have an OR of 1.9 (95% CI: 0.9 to 4). .0) The risk of esophageal cancer in men increases with the increase in smoking and length of smoking, and there is a significant dose-response relationship. Trend test P<0.01, women also show the same dangerous trend, but Most of them did not reach significant levels. Bruzzi’s method was used to estimate the percentage of people at risk of smoking (PAR%) adjusted for smoking among men in Huai’an City as 45.7% and women as 8.3%. This study did not find evidence linking esophageal cancer and drinking in Huai’an City. Conclusion Smoking is one of the most important causes of high incidence of esophageal cancer in Huai’an City. The effect of alcohol intake on esophageal cancer in Huaian City needs further study.