奈瑟淋球菌是淋病的主要病原体。近年随着抗生素的广泛使用 ,引起淋球菌耐药菌株的不断增多。本文综述了近年淋球菌耐药机制的研究进展。主要机制有 :产生抗生素代谢酶如 :β-内酰胺酶等 ,可导致对青霉素类抗生素的专一耐受 ;改变 PBPs、gyr A等胞内作用靶位点 ,逃避抗生素的毒性作用 ;Mtr主动外排系统及膜孔蛋白机制降低多种抗生素的有效浓度而导致对抗生素的多重耐药等。 Neisseria gonorrhoeae is the main pathogen of gonorrhea. In recent years, with the widespread use of antibiotics, gonococcal resistant strains caused by the continuous increase. This review summarizes the research progress of drug resistance mechanism of Neisseria gonorrhoeae in recent years. The main mechanisms are: the production of antibiotic metabolizing enzymes such as: β-lactamase, can lead to specific tolerance to penicillin antibiotics; change PBPs, gyr A intracellular target sites to escape the toxic effects of antibiotics; Mtr active Efflux system and membrane pore protein mechanism to reduce the effective concentration of a variety of antibiotics and lead to multiple antibiotic resistance.