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目的 探讨精神情绪因素与功能性胃肠病 (FGID)的关系及抗抑郁药对其的疗效。方法 对 6 2例FGID患者进行心理卫生自评表 (SCL - 90 )评分 ,其结果与我国常模标准分比较。然后按其消化道临床症状严重程度评分并随机分成二组 ,一组给予抗抑郁药 5 -羟色胺再摄取抑制剂 (SSRI)帕罗西汀 (赛乐特 )或氟西汀 (百忧解 ) ,均为 2 0mg/d ,疗程 8周后再重新予SCL - 90量表评分和消化道临床症状严重程度评分。另一组服用安慰剂相对照。结果 FGID患者SCL - 90总分和各因子分显著高于我国常模标准分 (P <0 0 5～ 0 0 0 1) ,其中焦虑和抑郁因子分最高。抗抑郁药治疗后 ,其SCL - 90总分和各因子分较前显著性下降 (P <0 0 5～ 0 0 0 1) ,且对改善消化道临床症状效果显著优于安慰剂组 (P <0 0 0 1)。结论 FGID患者存在精神情绪障碍 ,其中焦虑和抑郁情绪障碍尤为突出。抗抑郁药物在改善FGID患者精神情绪障碍的同时对改善其消化道症状有确切的疗效
Objective To explore the relationship between mental and emotional factors and functional gastrointestinal disease (FGID) and the effect of antidepressants on them. Methods Sixty patients with FGID were scored by SCL - 90, and the results were compared with the standard scores of norm in our country. The patients were then divided into two groups randomly according to the severity of the clinical symptoms of the digestive tract. One group was given Paroxetine (serotonin) or fluoxetine (Prozac), an antidepressant serotonin reuptake inhibitor (SSRI) 20 mg / d. After 8 weeks of treatment, the SCL - 90 scale score and the clinical severity of gastrointestinal tract were re - rated. The other group took placebo contrast. Results The score of SCL - 90 and the scores of SCL - 90 in FGID patients were significantly higher than those in China (P <0.05 ~ 0.01), with the highest score of anxiety and depression. After treatment with antidepressants, the scores of SCL - 90 and all factors decreased significantly (P <0.05-0.01), and were significantly better than placebo in improving clinical symptoms of gastrointestinal tract (P <0 0 0 1). Conclusion There are mental disorders in FGID patients, especially anxiety and depression disorders. Antidepressants have the exact effect of ameliorating their gastrointestinal symptoms while ameliorating psychiatric disorders in FGID patients