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头孢菌素近年来的发展非常迅速,无论就品种之多和其在治疗感染上的重要性来说,都是很令人感兴趣的,现已发展到称谓第三代头孢菌素的阶段。第三代头孢菌素不仅具有对第一、第二代头孢菌素无作用的绿脓杆菌有作用,对肠杆菌亦有良好作用。 羟羧氧头孢菌素(Ⅰ)是第三代头孢菌素的新成员,它是7-甲氧头孢菌素六元环中硫为氧取代的衍生物,是新的化学构型的化合物:
Cephalosporins have developed very rapidly in recent years. They are very interesting both in terms of varieties and their importance in the treatment of infections. Cephalosporins have now evolved to the third generation of cephalosporins. Third-generation cephalosporins not only have the first and second-generation cephalosporins play no role in the role of Pseudomonas aeruginosa, also have a good effect on Enterobacteriaceae. Hydroxycarboxylic cephalosporins (Ⅰ) is a new member of the third generation cephalosporins, which is sulfur-7-methoxy cephalosporin ring sulfur-oxygen-substituted derivatives, is a new chemical configuration compounds: