论文部分内容阅读
目的了解甲型H1N1流感密切接触者感染甲型H1N1流感病毒的危险因素。方法选择2009年5月16日～9月15日在北京发现的7 099名甲型H1N1流感密切接触者作为研究对象,根据流行病学调查资料,将其中感染甲型H1N1流感病毒者纳入病例组,未感染者纳入对照组,开展病例对照研究,通过单因素和多因素非条件Logistic回归分析探寻甲型H1N1流感密切接触者感染流感的危险因素。结果多因素分析结果显示:与>50岁的甲型H1N1流感密切接触者相比较,20～50岁(OR=3.57,95%CI:1.63～7.81)和<20岁(OR=8.29,95%CI:3.76～18.29)的密切接触者更有可能出现甲型H1N1流感病毒感染;与原发病例关系为家庭成员的密切接触者(OR=4.87,95%CI:3.32～7.13)、暴露于症状期原发病例的密切接触者(OR=1.87,95%CI:1.25～2.82)以及与原发病例暴露时间>12h的密切接触者(OR=1.81,95%CI:1.24～2.63)更易出现甲型H1N1流感病毒感染。结论密切接触者年龄低、与原发病例关系密切、暴露于症状期的原发病例、长时间暴露于原发病例是甲型H1N1流感密切接触者发生感染的危险因素。
Objective To understand the risk factors of Influenza A (H1N1) virus infection in close contacts with Influenza A (H1N1). Methods A total of 7 099 close contacts of influenza A (H1N1) virus, which were found in Beijing from May 16 to September 15, 2009, were selected as research subjects. According to the epidemiological survey data, those infected with the type A H1N1 influenza virus were included in the case group , Uninfected patients were included in the control group, to carry out case-control studies, single factor and multivariate non-conditional Logistic regression analysis of influenza A (H1N1) close contact with influenza risk factors. Results Multivariate analysis showed that patients aged 20 to 50 (OR = 3.57, 95% CI: 1.63 to 7.81) and <20 years (OR = 8.29, 95% CI: 3.76-18.29) were more likely to be swine influenza A (H1N1). In the first case, close contacts with family members were found (OR = 4.87, 95% CI: 3.32-7.13) (OR = 1.87, 95% CI: 1.25-2.82) and close contacts (OR = 1.81, 95% CI: 1.24-2.63) with primary exposure> 12 h H1N1 influenza virus infection. Conclusion The close contacts are of low age, closely related to the primary case, the primary case of exposure to the symptoms and long-term exposure to the primary case are the risk factors for the infection of the close contact with influenza A (H1N1).