目的:建立寒湿痹颗粒的质量标准。方法:采用薄层色谱法对处方中麻黄,甘草,桂枝,黄芪进行定性鉴别;采用高效液相色谱法对马兜铃酸A进行限量检查;采用高效液相色谱法测定芍药苷的含量。结果:薄层色谱中可检出麻黄,甘草,桂枝,黄芪,阴性均无干扰;芍药苷进样量在(0.029185~2.3348μg)范围内,线性关系(r=0.9999)良好。本方法平均回收率为99.5%,RSD为1.4(n=6)。结论:该方法准确,重复性好,可用于寒湿痹颗粒的质量控制。 Objective: To establish the quality standard of aloe-dampness granules. Methods: The prescription of Ephedra, Licorice, Cassia twig and Astragalus membranaceus was identified by TLC. The content of aristoloside A was determined by HPLC. The content of paeoniflorin was determined by high performance liquid chromatography. Results: There was no interference of ephedra, licorice root, cassia twig, astragalus membranaceus and feminine in thin layer chromatography. The linear relationship (r = 0.9999) was good between paeoniflorin in the range of (0.029185 ~ 2.3348μg) The average recovery of this method was 99.5% with a RSD of 1.4 (n = 6). Conclusion: The method is accurate and reproducible, and can be used for the quality control of Hanshanbi granules.