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应用双PAP法对22例GU,25例DU和10例胃癌患者的正常胃窦部粘膜G细胞分布密度进行了观察。结果显示DU组G细胞密度高于GU组和胃癌组(P<0.01),后两组G细胞密度差异不显著(P>0.05),提示DU的发生可能与G细胞密度增高、胃泌素产生过多、刺激壁细胞泌酸功能亢进有关,而GU的发生似与G细胞数量无明显关系。本文还观察了22例胃癌中的胃泌素型癌细胞,发现各型胃癌中均有少数癌细胞含有胃泌素,推测胃癌细胞可能来自胃的多能干细胞。
The double PAP method was used to observe the distribution of G cell density in normal gastric antrum of 22 GU, 25 DU and 10 gastric cancer patients. The results showed that the density of G cells in the DU group was higher than that in the GU group and the gastric cancer group (P<0.01). There was no significant difference in the G cell density between the two groups (P>0.05), suggesting that the occurrence of DU may be associated with an increase in the density of G cells and gastrin production. Too much, stimulating the hyperuricemia of the parietal cells is involved, and the occurrence of GU seems to have no obvious relationship with the number of G cells. This article also observed 22 cases of gastrin-type cancer cells in gastric cancer, found that all types of gastric cancer have a small number of cancer cells contain gastrin, presumably gastric cancer cells may be from the stomach of pluripotent stem cells.