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目的:考察阿托品输液的稳定性,探讨阿托品输液法抢救有机磷中毒患者的可行性。方法:建立RPHPLC法[色谱柱为NovaPakC184μm,3.9×150mm,流动相为甲醇/水(28∶72)]加入三乙胺0.12%,并用冰醋酸调pH5.0,检测波长210nm,流速0.8ml·min-1,柱温40℃,氢溴酸山莨菪碱做内标,检测临床应用条件下阿托品含量变化。另测定pH、不溶性微粒及外观变化。结果:在临床应用条件下阿托品含量、pH、外观24h稳定。经临床应用,阿托品输液法抢救有机磷中毒29例效果满意。结论:阿托品输液法抢救有机磷农药中毒是切实可行的。这对于中度、重度中毒患者减少被反复穿刺的痛苦、减少护理工作量具有重要的临床意义
Objective: To investigate the stability of atropine infusion and to explore the feasibility of atropine infusion in patients with organophosphate poisoning. Methods: The RPHPLC method was used [Column NovaPak C184μm, 3.9 × 150mm, mobile phase methanol / water (28:72)] was added 0.12% triethylamine and adjusted to pH5.0 with glacial acetic acid at a detection wavelength of 210nm and a flow rate of 0.8ml · min-1, column temperature 40 ℃, anisodamine hydrobromide as internal standard, detection of atropine content changes under clinical conditions. Another determination of pH, insoluble particles and appearance changes. Results: The atropine content, pH, appearance 24h stability under clinical application conditions. The clinical application of atropine infusion method to rescue organic phosphorus poisoning in 29 cases satisfied. Conclusion: Atropine infusion method for organophosphorus pesticide poisoning is feasible. This is for moderate and severe poisoning patients to reduce repeated pain pain and reduce the workload of nursing has important clinical significance