硫化氢是继内源性气体分子一氧化氮和一氧化碳被证实为信号分子后,发现的又一种新的气体信号分子,它广泛地参与了神经、心血管和消化等系统的生理功能调节。在心血管系统,硫化氢主要由胱硫醚γ裂解酶催化合成,参与了血管张力、心肌收缩力、肺动脉高压、动脉粥样硬化、血流动力学改变以及心肌损伤的调节,并与多种心血管疾病相关。 Hydrogen sulfide is another new gas signaling molecule discovered after the endogenous gas molecules nitric oxide and carbon monoxide are confirmed as signal molecules. It is widely involved in the regulation of physiological functions in the nervous, cardiovascular and digestive systems. In the cardiovascular system, hydrogen sulfide is mainly synthesized by cystathionine γ-lyase and is involved in the regulation of vascular tone, myocardial contractility, pulmonary hypertension, atherosclerosis, hemodynamic changes, and myocardial injury, and is associated with multiple heart Related to vascular disease.