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目的比较甲强龙与氢化可的松治疗慢性阻塞性肺病(COPD)急性加重期的临床疗效。方法选择2013年1—6月入住湖北省新华医院的COPD急性加重期患者62例,随机分为甲强龙组30例和氢化可的松组32例。甲强龙组给予甲强龙治疗,氢化可的松组给予氢化可的松治疗,比较两组的肺功能〔第1秒用力呼气容量(FEV1)、肺活量(FVC)〕和动脉血气分析指标。结果治疗后第3天两组FEV1、FVC、Pa O2、Pa CO2比较,差异无统计学意义(P>0.05),第10天两组FEV1、FVC、Pa O2、Pa CO2比较,差异有统计学意义(P<0.05)。结论甲强龙与氢化可的松治疗COPD急性加重期的疗效显著,甲强龙改善肺功能的效果优于氢化可的松。
Objective To compare the clinical efficacy of methylprednisolone and hydrocortisone in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Sixty-two patients with acute exacerbation of COPD admitted to Xinhua Hospital of Hubei Province from January to June 2013 were randomly divided into 30 cases of methylprednisolone group and 32 cases of hydrocortisone group. The methylprednisolone group was treated with methylprednisolone, while the hydrocortisone group was given hydrocortisone. The pulmonary function (FEV1, FVC) and arterial blood gas analysis index . Results There was no significant difference in FEV1, FVC, Pa O2 and Pa CO2 between the two groups on the third day after treatment (P> 0.05). On the 10th day, FEV1, FVC, Pa O2 and Pa CO2 between the two groups were statistically different Significance (P <0.05). Conclusion The efficacy of methylprednisolone and hydrocortisone in the treatment of acute exacerbation of COPD is significant, and the efficacy of methylprednisolone in improving pulmonary function is better than that of hydrocortisone.