(S)-邻氯苯甘氨酸是一种具有广泛用途的药物中间体,主要用于抗血小板聚集药物氯吡格雷的合成,其制备方法主要包括外消旋体拆分法和不对称合成法。重点对(S)-邻氯苯甘氨酸的制备方法进行了介绍,并比较了不同制备技术的优缺点,最后对(S)-邻氯苯甘氨酸的催化合成前景进行了展望。 (S) - o-Chlorophenylglycine is a widely used pharmaceutical intermediates, mainly for the synthesis of anti-platelet aggregation drug clopidogrel, its preparation methods include racemic resolution and asymmetric synthesis. The preparation methods of (S) - o - chlorophenylglycine were introduced emphatically. The advantages and disadvantages of different preparation techniques were compared. Finally, the prospects of the synthesis of (S) - o - chlorophenylglycine were prospected.