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Stepanik(1954)报告眼压和血液循环中的嗜酸性白细胞之间有着相反的关系,即一者的上升常伴同它者的下降。基于这种负相关的发现,他推论间脑垂体中枢一方面调整眼内压,另方面通过肾上腺皮质的激素控制血液循环中的嗜酸性白细胞数值。但是,1956年Cambiaggi及其同工作者不同意上述意见,因为他们重复Stepanik昼夜波动对比观察,并经统计学分析后,发现只有1/4的青光眼病人与该氏结果相符,
Stepanik (1954) reported that there is an inverse relationship between IOP and circulating eosinophils in the bloodstream, ie, the increase of one is often accompanied by a decrease of the other. Based on this negative correlation, he deduced that the pituitary gland regulates intraocular pressure on the one hand, and on the other hand controls the number of eosinophils in the blood circulation through hormones of the adrenal cortex. However, in 1956 Cambiaggi and colleagues disagreed with the above comments because they repeated the Stepanik diurnal contrast study and, after statistical analysis, found that only one-quarter of glaucoma patients were consistent with the findings,