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Non-structural protein 1(NS1) of the influenza virus plays a crucial role in modulating the host immune response and facilitating virus replication.The formation of a homodimer or an oligomer is necessary for NS1 to exert its function efficiently.In the present study,the NS1 protein from the A/Shantou/602/06(H3N2) virus(herein abbreviated as NS32) was found to interact with NS1 from A/Shantou/169/06(H1N1),A/Chicken/Guangdong/1/05(H5N1) and A/Quail/Hong Kong/G1/97(H9N2)(abbreviated as NS11,NS51 and NS92,respectively) viruses,although NS32 shares 17.4% 20.9% sequence diversity with NS11,NS51 and NS92.This indicates that the heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains may be a common event during co-infection.
Non-structural protein 1 (NS1) of the influenza virus plays a crucial role in modulating the host immune response and facilitating virus replication. The formation of a homodimer or an oligomer is necessary for NS1 to exert its function efficiently. In the present study, The NS1 protein from the A / Shantou / 602/06 (H3N2) virus (herein abbreviated as NS32) was found to interact with NS1 from A / Shantou / 169/06 (H1N1), A / Chicken / Guangdong / 1/05 H5N1) and A / Quail / Hong Kong / G1 / 97 (H9N2) (abbreviated as NS11, NS51 and NS92, respectively) viruses, although NS32 shares 17.4% 20.9% sequence diversity with NS11, NS51 and NS92.This indicates that the heterologous interactions between NS1 proteins from different influenza A virus subtypes / strains may be a common event during co-infection.