沙坦类药物是临床上治疗高血压的一线药物,包括洛沙坦、缬沙坦、厄贝沙坦、奥美沙坦、替米沙坦、坎地沙坦、依普沙坦等。文中对生物样品中此类降压药的色谱检测法作一综述,介绍作者的实验室使用的简单灵敏的色谱检测方法。这些新方法能促进沙坦类药物的药代动力学研究和低剂量给药药物浓度监测的发展,对于药物的进一步开发和临床用药浓度监测有非常重要的作用。 Sartan drugs are first-line drugs for the clinical treatment of hypertension, including losartan, valsartan, irbesartan, olmesartan, telmisartan, candesartan, eprosartan and so on. In this paper, the biological samples of such antihypertensive drugs chromatography detection methods are reviewed, the author’s laboratory using a simple and sensitive chromatography detection method. These new methods can promote the pharmacokinetics of sartan and the development of low-dose drug concentration monitoring, which play an important role in the further development of drug and the monitoring of clinical drug concentration.