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将30只健康雄性大耳白家兔分为对照组和治疗组,前者仅给基本饲料,后者从耳缘静脉一次注射5％Alloxan 140mg/kg,定期采血测血糖、血脂,定期解剖。结果证明,一次注射Alloxan后能引起血糖持续升高、尿糖阳性、胰岛B细胞广泛坏死、A细胞增生。至17周,胰岛细胞数目减少,以A细胞为主,胰岛大小不一,与晚期糖尿病人胰腺病变有相似之处。主动脉及肾动脉壁内可以看到脂质沉积,动脉内膜细胞增殖。注射Alloxan后一周内心、肝、肾呈现一定程度的损害,但大多数动物都能耐受,其后病变修复。说明用家兔以适当剂量的Alloxan复制糖尿病血管合并症模型是可行的。文内讨论了血管合并症发生机理。
Thirty healthy male large white rabbits were divided into control group and treatment group. The former fed only basic diet, the latter injected 5% Alloxan 140mg / kg once from the ear vein. Blood glucose and blood lipids were regularly measured and regularly dissected. The results show that, after a injection of Alloxan can cause sustained blood sugar, urine sugar positive, pancreatic B cell widespread necrosis, A cell proliferation. To 17 weeks, the number of islet cells decreased to A-cell-based, pancreatic islets of different sizes, with advanced diabetic patients with pancreatic lesions have similarities. Aortic and renal artery wall can be seen lipid deposition, arterial intima cell proliferation. One week after the injection of Alloxan, heart, liver and kidney showed a certain degree of damage, but most animals were able to tolerate, and subsequently the lesion was repaired. Alloxan rabbit with an appropriate dose of replication of diabetic vascular comorbidity model is feasible. The article discusses the pathogenesis of vascular complications.