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目的 研究模拟失重对心脏形态的影响及其用四肢加压套带和下体负压的拮抗作用 .方法 自愿接受试验的健康男性青年 18名 ,年龄 19～ 2 5 (平均 2 2 .6 )岁 ,随机分为对照组 ,套带组和下体负压组 ,进行 2 1d6°头低位卧床试验 .对照组卧床中不用任何对抗措施 ;套带组卧床期间每日 0 8∶ 30～2 0∶ 30 ,四肢戴加压套带 ,压力维持在 5 .3k Pa;下体负压组卧床期间第 1wk和最后 1wk每日 15 :0 0使用 1h下体负压裤 ,压力维持在 - 4k Pa.所有组均分别于卧床前 1d和卧床结束后 1d摄取 X线胸片各 1张 ,测量胸廊横径、心脏横径、长径和宽径 ,并计算反映心脏形态大小的心胸比和心脏面积 .结果 对照组心脏横径减少 0 .5 4cm,心胸比减少 0 .0 2 4,心脏面积减少 9cm2 ,前后比较均有明显差异 (P<0 .0 5 ) ;套带组分别减少 0 .5 0 cm,0 .0 2 1和 1.9cm2 ,前后比较无显著性差异 (P>0 .0 5 ) ;下体负压组各指标变化不明显 (P>0 .0 5 ) .结论 头低位卧床模拟失重对心脏形态有明显的影响 ,而四肢加压套带和下体负压均可拮抗失重对心脏形态的作用
Objective To study the effect of simulated weightlessness on cardiac morphology and the antagonism of negative pressure with the four-limbed compression cord and lower body.Methods Eighteen healthy male volunteers were randomly enrolled in this study, ranging in age from 19 to 25 (mean, 22.6 years) Were randomly divided into control group, cuff group and lower body negative pressure group for 21d6 ° head-down bed test.Control group did not use any countermeasures in the bed; The pressure was maintained at 5.3k Pa on all limbs and the negative pressure group was 1hk and 1wk daily at 15w during the ambulatory period in the lower body. The pressure was maintained at -4kPa for 1h under body negative pressure pants, One chest X-ray was taken one day before bedtime and one day after bed rest, and the chest diameter, heart diameter, long diameter and width were measured, and the ratio of heart to chest reflecting heart shape and heart area were calculated.Results The control group Heart diameter decreased 0.54 cm, heart-chest ratio decreased 0. 02 4, heart area decreased 9 cm 2, before and after comparison were significantly different (P <0. 05); .0 2 1 and 1.9cm2, there was no significant difference between before and after (P> 0.05) (P0.05) .Conclusion The simulated head-weight bed weight loss has a significant effect on the morphology of the heart, while the pressure exerted by the extremities and the lower body negative pressure can antagonize the effect of weightlessness on the morphology of the heart