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选用１５３Ｓｍ对生物素进行放射性标记，然后利用亲和素和链霉亲和素与生物素的高亲合力特性，再对亲和素和链霉亲和素进行１５３Ｓｍ的标记，观察在大鼠和小鼠体内的血清除率和生物学分布，并与１５３ＳｍＣ１３和１５３Ｓｍ－ＤＴＰＡ的生物学分布进行比较．结果表明，１５３Ｓｍ标记的亲和素血清除迅速，肝肾放射性摄取高；１５３Ｓｍ标记的链霉亲和素血清除缓慢，肝、脾、肾等脏器和血液中滞留量高；而１５３Ｓｍ－生物素的代谢较快，其血清除主要经肾脏排泄。亲和素和链霉亲和素体内生物分布的差别为预定位放免显像和治疗研究中亲和素－生物素系统的不同组分的选择提供实验基础。
153Sm was used to radiolabel the biotin, and then using avidin and streptavidin and biotin high affinity characteristics, and then avidin and streptavidin 153Sm labeling observed in rats and Serum clearance and biodistribution in mice were compared to the biodistribution of 153SmC13 and 153Sm-DTPA. 153Sm labeled streptavidin serum in addition to slow, liver, spleen, kidney and other organs and blood retention was high; 153Sm-biological Su metabolites faster, in addition to its main serum excretion by the kidneys. Differences in the biodistribution of avidin and streptavidin in vivo provide an experimental basis for the selection of different components of the avidin-biotin system in a targeted radioimmunoassay and therapeutic study.