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采用放射性生物微球技术观察了经受４０和１２０ｄ尾部悬吊模拟失重大鼠冠脉血流量及冠脉阻力的变化。４０及１２０ｄ悬吊大鼠冠脉血流量分别较其相应对照组减少２５％（Ｐ＜０．０１）和２２％（Ｐ＜０．０５）；而４０ｄ组和１２０ｄ组的冠脉阻力与其相应配对对照组相比分别升高３７％（Ｐ＜０．０５）和３１％（Ｐ＜０．０５）。此外，悬吊４０ｄ与悬吊１２０ｄ组大鼠左心室重量分别较其配对的对照组大鼠要减轻９％（Ｐ＜０．０５）及５％（Ｐ＜０．０１）。结果表明，长期模拟失重大鼠心脏可能处于低动力状态，从而使心肌的代谢活动减弱并可能发生萎缩。
The changes of coronary blood flow and coronary resistance in 40-day and 120-day tail-suspended simulated weightless rats were observed by radioactive microsphere technique. The coronary flow in 40 and 120 d-suspended rats decreased by 25% (P <0.01) and 22% (P <0.05), respectively, compared with the corresponding control group Compared with the control group, they were increased by 37% (P <0.05) and 31% (P <0.05), respectively. In addition, left ventricular weight of rats in the 40d and 120d groups were 9% (P <0.05) and 5% (P <0.01) lower than those of the matched control rats respectively. The results show that long-term simulated weightless rat heart may be in a low dynamic state, so that myocardial metabolic activity weakened and possible atrophy.