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目的 :研究大鼠中缝背核至背海马投射纤维的递质性质。方法 :用辣根过氧化物酶 (HRP)逆行追踪法和免疫细胞化学相结合的双重标记技术研究中缝背核 5 羟色胺 (5 HT)样神经元至背海马投射。结果 :在中缝背核内可见到HRP标记细胞、5 HT阳性反应细胞和 5 HT HRP双标细胞。结论 :中缝背核 5 HT样神经元至背海马投射为进一步研究海马的生理功能提供了有价值的形态学资料
OBJECTIVE: To study the neurotransmitter properties of the dorsal raphe nucleus to the dorsal hippocampus in rats. Methods: The dorsal hippocampal projections of serotonergic (5 HT) -like neurons in dorsal raphe nucleus were studied by double labeling technique combined with retrograde tracing of horseradish peroxidase (HRP) and immunocytochemistry. RESULTS: HRP labeled cells, 5 HT positive cells and 5 HT HRP double labeled cells were found in the dorsal raphe. CONCLUSION: Projections of 5 HT-like neurons to the dorsal hippocampus of the dorsal raphe nucleus provide valuable morphological data for the further study of the physiological functions of the hippocampus