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目的:探讨降钙素原水平(procalcitonin,PCT)在胆道感染中的变化及意义.方法纳入2012年2月~2013年2月我院住院的胆道感染患者358例,其中男176例,女182例,年龄19~86岁,平均(42.56±13.21)岁,其中单纯胆囊结石179例,胆总管结石76例(同时合并胆囊结石者31例),肝内外多发胆管结石89例,胆道肿瘤14例,按是否接受手术分为手术组(胆囊切除、胆总管切开取石、肝叶切除、胆肠吻合等)、非手术组(包括单纯药物治疗、经内镜逆行胆胰管造影、内镜下十二指肠乳头括约肌切开术、内镜下鼻-胆管引流术、经皮经肝胆管引流术等).以上病例确诊均通过血液、胆汁等标本获得病原学证据以及临床表现支持.结果比较胆道感染有效治疗过程中PCT数据差异性,随着时间推移,手术组和非手术组内的PCT值呈下降趋势,第3天与第1天、第5天与第3天比较,均差异有统计学意义(P<0.05),手术组和非手术组在同一时间点(第1、3天)测得PCT值差异有统计学意义(P0.05).结论 PCT值能较好反映了病情变化,监测血清PCT浓度,有助于指导胆道感染治疗和病情评估.相对于非手术组,手术组患者具有较高的PCT值. “,”Objective To investigate procalcitonin(PCT for short)in the changes and the significance in the treatment of biliary tract infection. Methods Selected 358 cases of patients with biliary tract infection admitted to our hospital from Feb. 2012 to Feb. 2013.Among these cases, 176 patients were males, and 182 cases were females. Their ages varied from 19 to 86 years old(mean 42.56±13.21 years),including 179 cases with simple cholecystolithiasis, 76 cases with choledocholithiasis(31 cases complicated with cholecystolithiasis),89 cases with intrahepatic and extrahepatic biliary calculi,14 cases with biliary neoplasms. Patients were divided into operation group and non operation group. Operation group was underwent cholecystectomy, choledocholithotomy, liver resection, biliary enteric anastomosis, etc. Non operation group received treatment of drug therapy, endoscopic retrograde cholangio-pancreatography, endoscopic sphincterotomy, endoscopic naso-biliary drainage, percutaneous transhepatic cholangial drainage,etc. All cases were conifrmed with etiological evidence through samples of bloold or bile and clinical manifestation. Results PCT levels were compared during the process of effective treament of biliary tract infection. As time went by, a downward trend of PCT levels was seen in operation group and non operation group. PCT levels in both groups had signiifcant difference between day 1 and day 3, day 3 and day 5(P0.05). Conclusion PCT can reflect the changes of disease. Therapy and severity evaluation of cholangeitis can be guided by PCT detection. Compared with the non operation group,PCT levels were higher in operation group.