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目的探讨地诺前列酮栓用于足月妊娠产妇促宫颈成熟的临床效果。方法 82例足月妊娠待产孕妇随机分为观察组和对照组各41例,分别给予地诺前列酮栓、催产素促宫颈成熟,比较2组给药后12,24h宫颈Bishop评分、促宫颈成熟有效率,临产、胎膜破裂阴道分娩总产程时间、胎儿窘迫发生率、剖宫产率、产后出血量、新生儿出生体质量、新生儿窒息发生率及药物不良反应发生情况。结果观察组给药后12,24h宫颈Bishop评分、促宫颈成熟有效率高于对照组(P<0.05),临产时间、胎膜破裂时间、剖宫产率均低于对照组(P<0.05);2组胎儿窘迫发生率、产后出血量、经阴道分娩总产程、新生儿出生体质量比较差异无统计学意义(P>0.05)。结论地诺前列酮栓用于足月妊娠产妇促宫颈成熟效果满意。
Objective To investigate the clinical effect of dinoprostone suppository on cervix maturation in term pregnant women. Methods 82 pregnant women with term pregnancy were randomly divided into observation group and control group, 41 cases in each group. Patients were given droperidol suppository and oxytocin to promote cervical ripening. The cervical Bishop score at 12 and 24 hours after administration was compared to promote cervical ripening Effective, labor, duration of vaginal delivery during fetal rupture of membranes, fetal distress rate, cesarean section rate, postpartum hemorrhage, newborn birth weight, neonatal asphyxia and adverse drug reactions. Results The effective rate of cervical Bishop score and cervical ripening in observation group was higher than that of control group (P <0.05) at 12 and 24 hours after administration. The duration of labor, rupture of fetal membranes and cesarean section were all lower than those in control group (P <0.05) There were no significant differences in the incidence of fetal distress, postpartum hemorrhage, total labor during vaginal delivery, and neonatal birth weight (P> 0.05). Conclusions The use of dinoprost suppository for full-term pregnancy maternal cervical ripening satisfactory results.