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为探讨新生儿缺氧缺血性脑病的发病机理，选用健康新生猪24只并随机分为正常对照组（A组）、缺氧缺血性脑损伤（HIE）后2小时组（B组）及HIE后24小时组（C组）。采用放射配体结合法检测各级脑组织突触膜上谷氨酸受体（GluR），结果发现HIE后24小时GluR的最大结合住点数（Bmax）：12．4±2.1pmol／mg蛋白，显著低于A组（17.4±3．1pmol／mg蛋白）和B组，但各组间GluR的亲和力（Kd）均无显著性差异。结果提示，GlUR的改变可能参与了新生猪HIE的发病。
To explore the pathogenesis of neonatal hypoxic-ischemic encephalopathy, 24 healthy newborn pigs were selected and randomly divided into normal control group (A group), hypoxia-ischemic brain injury (HIE) 2 hours group (B group) And 24 hours after HIE group (C group). Radioligand binding assay was used to detect glutamate receptor (GluR) on synapse of brain tissue at all levels. The maximum binding sites (Glu) of GluR at 24 hours after HIE were found to be 12.4 ± 2.1 pmol / mg protein, significant Lower than that in group A (17.4 ± 3.1pmol / mg protein) and group B, but there was no significant difference in the affinity of GluR between groups (Kd). The results suggest that the change of GlUR may be involved in the pathogenesis of neonatal pig HIE.