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目的探讨重型肝炎及活动性肝硬化并发医院感染的病原菌、感染部位及临床耐药与疾病转归。方法对2006年1月至2009年10月住院的40例重型肝炎及活动性肝硬化患者合并感染培养阳性患者的病原菌进行回顾性研究。结果 304例患者并发医院感染者40例,感染率为13.16%。细菌感染者以革兰氏阴性杆菌为主,主要感染部位为呼吸道,真菌感染者以白色念珠菌为主。结论本院重型肝炎及肝硬化并发医院感染的主要危险因素与肝脏储备功能下降、有创性操作及预防性应用抗生素有关。
Objective To investigate the pathogens, infection sites, clinical resistance and disease outcomes of nosocomial infections in patients with severe hepatitis and active cirrhosis. Methods A retrospective study was conducted on the pathogenic bacteria in 40 patients with severe hepatitis and active cirrhosis who were admitted to hospital from January 2006 to October 2009. Results 304 patients with nosocomial infection in 40 cases, the infection rate was 13.16%. Gram-negative bacilli mainly bacteria, the main part of the respiratory tract infection, fungal infections mainly Candida albicans. Conclusions The main risk factors for nosocomial infections associated with severe hepatitis and cirrhosis in our hospital are associated with decreased liver reserve, invasive procedures and prophylactic antibiotics.