马凡氏综合征(Marfan syndrome,MFS)是一种遗传性结缔组织病,由法国医生Antoine Marfan在1896年首先描述[1]。它是一组因先天性间质组织缺陷导致的临床综合征,临床表现复杂多样,可累及骨骼系统、心血管系统、视觉系统、肺及中枢神经系统等。MFS常合并脊柱畸形,其中以脊柱侧凸最为常见,且偶可累及同一家族中 Marfan syndrome (MFS) is a hereditary connective tissue disease that was first described by French physician Antoine Marfan in 1896 [1]. It is a group of clinical syndromes caused by defects of congenital interstitial tissue. The clinical manifestations are complex and diverse and can affect the skeletal system, cardiovascular system, visual system, lung and central nervous system. MFS often associated with spinal deformity, of which scoliosis is the most common, and even can involve the same family