论文部分内容阅读
目的了解本院临床分离菌株的分布及耐药性。方法采用抗菌药物MIC和纸片扩散法药敏试验。参照CLSI2014年版标准判读药敏结果,用WHONET 5.6软件进行总结分析。结果 2014年11月-2015年11月共收集非重复临床分离菌株4 998株,革兰阴性菌3 378株,占67.6%;革兰阳性菌1 620株,占32.4%。居前5位的细菌依次为大肠埃希菌(22.3%)、肺炎克雷伯菌(13.2%)、鲍曼不动杆菌(9.5%)、铜绿假单胞菌(7.2%)、金黄色葡萄球菌(7.1%)。肠杆菌科细菌、铜绿假单胞菌、鲍曼不动杆菌对亚胺培南和美罗培南的耐药率分别为<3%、<20%、<50%。耐甲氧西林金黄色葡萄球菌的检出率为12.4%,耐甲氧西林凝固酶阴性葡萄球菌占81.1%,未检出耐万古霉素和耐利奈唑胺的菌株。检出耐万古霉素粪肠球菌1株,屎肠球菌3株。结论山西大医院临床分离菌株以革兰阴性杆菌为主,与全国耐药监测数据相符,耐药情况不容忽视。
Objective To understand the distribution and drug resistance of clinical isolates in our hospital. Methods Antibiotics MIC and disk diffusion method drug susceptibility testing. According to the CLSI2014 edition, the results were analyzed by WHONET 5.6 software. Results A total of 4 998 non-repetitive clinical isolates, 3 378 Gram-negative bacteria, accounting for 67.6%, were collected from November 2014 to November 2015, while 1 620 strains of Gram-positive bacteria accounted for 32.4%. The top five bacteria were Escherichia coli (22.3%), Klebsiella pneumoniae (13.2%), Acinetobacter baumannii (9.5%), Pseudomonas aeruginosa (7.2%), golden yellow grape Cocci (7.1%). Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter baumannii resistance rates to imipenem and meropenem were <3%, <20%, <50%, respectively. The detection rate of methicillin-resistant Staphylococcus aureus was 12.4%, methicillin-resistant coagulase-negative staphylococci accounted for 81.1%, vancomycin-resistant and linezolid-resistant strains were not detected. 1 isolates of vancomycin-resistant Enterococcus faecalis and 3 strains of Enterococcus faecium were detected. Conclusion The clinical isolates from Shanxi University Hospital are mainly Gram-negative bacilli, which are consistent with the national surveillance data of drug resistance. Drug resistance can not be ignored.