丙型肝炎由丙型肝炎病毒(hepatitis C virus,HCV)感染引起,感染者呈全世界分布。丙型肝炎病毒有6种主要的基因型,感染在献血或吸毒人群中多见,感染后少数患者发生病毒的自发性清除,未清除者病情容易慢性化,可能进一步发展为肝硬化、肝癌,危害着人类的健康。目前,多个对丙型肝炎自然史及其影响因素的研究结果出现了不一致性,其中饮酒是影响疾病进展非常重要的因素。 Hepatitis C is caused by hepatitis C virus (HCV) infection and is distributed worldwide. Hepatitis C virus has six major genotypes, infection in the blood donation or drug users more common, a small number of patients infected with virus spontaneous clearance, the disease is easy to be chronic disease, may further develop into cirrhosis, liver cancer, Endanger human health. At present, there are inconsistencies in the results of several studies on the natural history of hepatitis C and its influencing factors, of which drinking is a very important factor affecting the progression of the disease.