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背景与目的确诊的非小细胞肺癌(NSCLC)患者中,65%～70%为晚期(Ⅲ、Ⅳ期)。对于这类患者,采用综合治疗有望取得较好的治疗效果。本研究的目的是探讨晚期NSCLC(ⅢB、Ⅳ期)以手术为主综合治疗的疗效。方法总结分析北京协和医院胸外科1995～2003年部分接受以手术为主综合治疗的ⅢB～Ⅳ期NSCLC患者的临床资料,通过评估患者的生存率,评价以手术为主综合治疗的疗效。结果全组51例患者,ⅢB期20例,Ⅳ期31例,总体中位生存期为37.0月±7.6月,术后1年生存率为86.35%±5.21%,3年生存率为52.96%±8.83%。结论以手术为主的综合治疗有望提高可手术晚期NSCLC患者的生存期。
Background and Purpose Of the 65 patients diagnosed with non-small cell lung cancer (NSCLC), 65% to 70% are late (stage III, IV). For such patients, the use of comprehensive treatment is expected to achieve better therapeutic effect. The purpose of this study was to investigate the efficacy of primary surgery in the treatment of advanced NSCLC (Stage IIIB, Stage IV). Methods The clinical data of patients with stage ⅢB ~ Ⅳ NSCLC who were treated mainly by surgery from 1995 to 2003 in Department of Thoracic Surgery, Peking Union Medical College Hospital in Beijing were summarized and analyzed. The survival rate of patients with stage ⅢB ~ Ⅳ NSCLC was evaluated. The curative effect of surgery - based comprehensive treatment was evaluated. Results The overall group of 51 patients, 20 cases of stage Ⅲ B, 31 cases of stage Ⅳ, the overall median survival was 37.0 months ± 7.6 months, 1-year survival rate was 86.35% ± 5. 21%, 3-year survival rate was 52.96% ± 8.83%. Conclusion Surgical-based comprehensive treatment is expected to improve the survival of patients with advanced NSCLC.