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用离体大鼠心脏模型研究甲巯丙脯酸对消心痛(ISDN)引起血管扩张反应的影响,并与半胱胺酸(无血管紧张素转移酶活性的含巯基化合物)和Ramiprilate(不含巯基的血管紧张素转移酶抑制剂)进行疗效比较.将雄性大鼠的离体心脏随机分为4组,每组6个,按Langendorff方法在60mmHg恒压下灌注,平衡后,离体心脏分别用不同药物灌注,每次灌注10min,再清洗10min.A组用8μg/ml甲巯丙脯酸或40μg/ml
The effect of captopril on vasodilator response induced by or without heartburn pain (ISDN) was studied with an isolated rat heart model and compared with cysteine (thiol-free compounds with angiotensin-converting enzyme activity) and Ramiprilate Mercapto-angiotensin-converting enzyme inhibitor) were used to compare the therapeutic effects.Exposed hearts of male rats were randomly divided into 4 groups, 6 in each group, perfusing under the constant pressure of 60mmHg by Langendorff method, Perfusion with different drugs, each perfusion 10min, and then washed 10min.A group with 8μg / ml captopril or 40μg / ml