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为了解细胞免疫调节在糖尿病肾病中的作用，将41例NIDDM患者按24小时尿蛋白分组，用间接免疫荧光法测定T细胞亚群和白介素-2膜受体（mIL－2R）。结果显示，合并蛋白尿者CD8+细胞增高、CD4+／CD8+值降低。mIL－2R表达增强，CD8+、mIL－2R和尿蛋白呈正相关，CD4+／CD8+值和尿蛋白呈负相关，多元逐步回归分析显示CD4+／CD8+、mIL－2R、CD8+依次是糖尿病肾病相关危险因素。结果提示细胞免疫调节紊乱可在一定程度上影响糖尿病肾病。
To understand the role of cellular immune regulation in diabetic nephropathy, 41 patients with NIDDM were divided into 24-hour urine protein groups and T cell subsets and interleukin-2 receptor (mIL-2R) were measured by indirect immunofluorescence. The results showed that CD8 + cells with proteinuria increased, CD4 + / CD8 + value decreased. The positive expression of mIL-2R, CD8 +, mIL-2R and urinary protein were positively correlated. The CD4 + / CD8 + values were negatively correlated with urinary protein. Multiple stepwise regression analysis showed that CD4 + / CD8 +, mIL-2R and CD8 + were the risk factors of diabetic nephropathy. The results suggest that cellular immune dysregulation may affect diabetic nephropathy to a certain extent.