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近年来,不断发现某些历史较长的传统“老药”,在临床应用中显示出超越以往适应症的范畴。例如灭滴灵除治疗阴道滴虫外,又发现具抗厌氧菌作用,而用于治疗急性口腔感染以及非感染性疾病如克罗恩氏病(Crohn’s disease)等;氨苯砜除治疗麻风以外,又可作为治疗天疱疮、类天疱疮及盘状红斑狼疮等的药物;又例例阿司匹林用于抗血栓;灰黄霉素在治疗非真菌性感染的某些粘膜、皮肤病方面,也显示了一定疗效。因此,“老药新用”已成为国际上的新课题。兹将灰黄霉素在治疗扁平苔藓(LP)方面的近况及有关问题予以综述。一、应用历史灰黄霉素由灰黄青霉菌(Penicillium griseo-fulvin)及其他几种青霉菌属产生。1939年Oxford等首先从灰黄青霉菌属中分离得到灰黄霉素。
In recent years, it has been discovered that some of the traditional “old drugs” with a long history have shown their surpassing of past indications in clinical application. For example, metronidazole in addition to the treatment of vaginal trichomoniasis, but also found to have anti-anaerobic bacteria, and for the treatment of acute oral infections and non-infectious diseases such as Crohn's disease, etc.; dapsone other than leprosy As a treatment for pemphigus, pemphigoid and discoid lupus erythematosus and other drugs; another example aspirin for anti-thrombosis; griseofulvin in the treatment of non-fungal infections of some mucosal, skin diseases, also showed A certain effect. Therefore, “old medicine and new use” has become a new international issue. The current status of griseofulvin in the treatment of lichen planus (LP) and related issues are reviewed. Application History Griseofulvin is produced by Penicillium griseo-fulvin and several other Penicillium species. In 1939, Oxford et al. First isolated griseofulvin from Penicillium funiculosum.