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采用超临界 CO2 流体技术对红曲中胆固醇抑制物进行萃提 ,获得较佳条件如下 :温度 55℃ ,压力 2 2 MPa,时间 1 5min,粒度 (D) 2 mm。同时 ,根据实验判断 ,可能有超临界流体的细胞破壁作用。 6号萃提条件获得较佳结果。从三个吸收特征峰 2 30、2 37,2 4 7nm处选择吸收较强的峰 ,以减少相对误差。萃提率 =A超临界法 /A溶剂法。天然产物于超临界CO2 的流体中呈弱酸性 ,这与 Monacolin类物资溶剂萃提所需的 PH环境一致。从萃提率可知 ,超临界 CO2 对红曲中的胆固醇合成抑制物 Monacolin类物资的萃提效果较溶剂萃提方法好 ,这可能与超临界流体的细胞破壁功能有关。
The supercritical CO2 fluid technology was used to extract the cholesterol inhibitor in the red yeast rice. The optimum conditions are as follows: temperature 55 ℃, pressure 22 MPa, time 15 min, particle size (D) 2 mm. At the same time, according to the experimental judgment, there may be cell wall breaking of the supercritical fluid. 6 stripping conditions for better results. From the three absorption characteristic peaks 2 30,2 37,2 4 7nm choose strong absorption peak, to reduce the relative error. Extraction rate = A supercritical / A solvent method. The natural product is weakly acidic in the supercritical CO2 fluid, which is consistent with the pH environment required for solvent extraction of Monacolin species. From the extract rate, supercritical CO2 extraction of Monacolin, a cholesterol synthesis inhibitor of Monascus, is better than that of solvent extraction, which may be related to the cell wall breaking function of supercritical fluid.