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本文对纤维胃镜证实的41例消化性溃疡患者进行了随机、对照研究。结果表明:“胃忧愈”治疗组8周病状消失率达80.0％,愈合率为75.0％,疗效与甲氰咪胍组相似(后者各为76.2％、66.7％),但本药对幽门螺杆菌(Helicobacter pylori, HP)的清除率(45.0％),合并的慢性胃窦炎好转率(50.0％)和慢性胃炎急性活动消失率(55.0％)显著高于对照组(分别为19.0％,14.3％,14.3％)。动物实验表明该方剂对无水乙醇所致胃粘膜损伤具有细胞保护作用。其机制与胃粘膜PGE_2、胃酸无关,而与促进胃粘液分泌,加强粘液—碳酸氢盐屏障有关。
In this paper, 41 patients with peptic ulcer confirmed by fiber endoscopy were randomized and controlled. The results showed that the disappearance rate of symptoms and signs in the treatment group “Weiweiyu” for 8 weeks was 80.0% and 75.0%, respectively. The curative effect was similar to that of the cimetidine group (the latter 76.2% and 66.7%, respectively) Helicobacter pylori (HP) clearance (45.0%), combined chronic antral gastritis (50.0%) and chronic gastritis (55.0%) were significantly higher than those in the control group (19.0% 14.3%, 14.3%). Animal experiments show that the prescription of ethanol-induced gastric mucosal injury with cytoprotective effect. The mechanism of gastric mucosal PGE2, gastric acid has nothing to do, but with the promotion of gastric mucus secretion, strengthen mucus - bicarbonate barrier.