细胞凋亡(Apoptosis,apo)是机体进行生理性细胞代谢,清除细胞的重要途径,在淋巴细胞发育分化成熟过程中扮演重要角色,通过 apo 使可能导致自身免疫疾病的细胞凋亡而加以清除.PCNA 存在于细胞核内,是 DNA 聚合酶的辅助因子,参与DNA 的合成,并在细胞周期中起着重要的调控作用.PCNA 的周期性变化与细胞增殖过程有关.目前认为肿瘤的发生与细胞 Apoptosis (apo) is an important pathway for the body to metabolize and eliminate cells. It plays an important role in the development and differentiation of lymphocytes and can be cleared by apo, which may lead to the apoptosis of autoimmune diseases. PCNA is present in the nucleus, is a DNA polymerase cofactor, involved in the synthesis of DNA, and plays an important regulatory role in the cell cycle.PCNA cyclical changes and cell proliferation process is currently believed that the occurrence of cancer and cells