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本文收集慢粒骨髓标本慢性期35例,加速期2例,急变期4例,缓解期3例。共计44例。用PAS染色和直接法分别检查PAS—IBM和PH染色体。结果在慢性期PAS—IBM31/35阳性,PH染色体32/35阳性;加速期 PAS—TBM2/2阳性,PH染色体2/2阳性;急变期PAS—IBM1/4阳性,PH染色体3/4阳性。缓解?PAS—IBM23阳性,Ph染色体3/3阳性。而在PH染色体阴性的4例,均检出PAS—IBM。结果表明,在慢粒的慢性期,两项的阳性检出率颇为接近(分别为88.6%和91.4%),故认为PAS—IBM和PH染色体同样对慢粒的诊断具有重要价值。但前者尚可检出PH染色体阴性病利,且因其经济、简便、快速,有利于在各级医院推广应用。
In this paper, 35 patients with chronic myeloid bone marrow samples were collected, 2 cases of acceleration, 4 cases of acute phase and 3 cases of remission. A total of 44 cases. PAS-IBM and PH chromosomes were examined by PAS staining and direct method, respectively. Results PAS-IBM31 / 35 was positive in chronic phase, PH 32/35 positive in accelerated phase; PAS-TBM2 / 2 was positive in accelerated phase and 2/2 was positive in PH chromosome; PAS-IBM1 / 4 was positive in blast phase and 3/4 was positive in PH chromosome. Ease PAS-IBM23 positive, Ph chromosome 3/3 positive. In PH-negative 4 cases, were detected PAS-IBM. The results showed that in the chronic phase of CML, the positive detection rates of the two were quite similar (88.6% and 91.4% respectively), so PAS-IBM and PH chromosomes are also of great value in the diagnosis of CML. However, the former can still detect PH-negative disease Lee, and because of its economic, simple and rapid, conducive to the promotion and application of hospitals at all levels.