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[目的 ]研究听觉系统在脉冲噪声作用下的损伤特点以及在脉冲噪声环境下苯异丙腺苷 (R phenylisopropy ladenosine ,R PIA ,见SigmaChemicals)对听觉系统的保护作用。 [方法 ]将 6只灰鼠 (chinchillas)暴露于 10 0个 15 0dBSPL脉冲噪声中 ,暴露前 2h在其右耳用药 (R PIA 0 1mmol/L ,3 0 μl) ,左耳为对照。脉冲噪声是模拟M 16来福枪而成。[结果 ]对照组 (左耳 )的永久性阈移 (PTS)在 2 2～ 40dB之间 ,用药组 (右耳 )的PTS比对照组少 8～ 13dB。其用药组的外、内毛细胞缺失率明显比对照组少 (10～ 5 0 %、15～ 45 % )。 [结论 ] 15 0dBSPL的脉冲噪声所造成的听觉系统损伤大大超过等能量的稳态噪声 ;R PIA可有效地保护听觉系统免受脉冲噪声的危害
[Objective] The research aimed to study the damage characteristics of auditory system under impulsive noise and the protective effect of R phenylisopropy ladenosine (R PIA, see Sigma Chemicals) on auditory system in impulsive noise environment. [Method] Six chinchillas were exposed to 10 0 SPSPL impulsive noise. The right ear was treated with R PIA 0 1 mmol / L, 30 μl 2 h before exposure and the left ear was used as control. Impulse noise is simulated M 16 rifle made. [Results] The permanent threshold shift (PTS) of the control group (left ear) was between 22 and 40 dB, and the PTS of the medication group (right ear) was 8 ~ 13 dB less than that of the control group. The drug group, the inner hair cell loss rate was significantly less than the control group (10 ~ 50%, 15 ~ 45%). [Conclusion] The auditory system damage caused by impulse noise of 15 0 dBSPL greatly exceeds the steady-state noise of equal energy. R PIA can effectively protect the auditory system from impulse noise