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采用单克隆抗体,对一组乳腺肿瘤作了癌基因C-erbB-2表达产物的免疫组织化学研究,结果发现浸润性癌65％(65/100)、导管内癌72％(36/50)、Paget’s病80％(16/20)及导管内乳头状瘤病30％(6/20)有C-erbB-2的过度表达,提示这些肿瘤有C-erbB-2基因扩增。癌基因产物主要位于细胞膜。在浸润性癌C-erbB-2的过度表达与腋窝淋巴结转移及肿瘤细胞核分裂数增多呈正相关,提示C-erbB-2的过度表达与较差的预后有一定关系。
An immunohistochemical study of an oncogene C-erbB-2 expression product was performed on a group of breast tumors using a monoclonal antibody. The results showed that 65% (65/100) of invasive cancers and 72% (36/50) of intraductal cancers were found. Overexpression of C-erbB-2 was found in 80% (16/20) of Paget’s disease and 30% (6/20) of intraductal papillomatosis, suggesting that these tumors have C-erbB-2 gene amplification. The oncogene product is mainly located on the cell membrane. The overexpression of C-erbB-2 in invasive carcinomas was positively correlated with axillary lymph node metastasis and increased number of tumor cells, suggesting that C-erbB-2 overexpression has a certain relationship with poor prognosis.