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子痫前期是胎盘滋养细胞浸润功能障碍.因滋养细胞浸入子宫内膜层较浅,仅达蜕膜层,同时并发子宫血管重铸障碍,引起胎盘组织缺血、缺氧,引起一系列子痫前期临床表现.近年研究认为Rho蛋白是鸟苷三磷酸结合蛋白,其下游分子为Rho相关卷曲螺旋形成蛋白激酶(Rock),Rho/Rock信号通路对细胞内微丝骨架的聚合状态进行调控,进而对细胞的行为和功能进行调节,如细胞的黏附、游走、收缩及癌细胞的浸润和转化等,参与多种疾病的发病.笔者就滋养细胞浸润能力的调控和Rho/Rock信号通路活化、调节等功能及与妊娠的关系作一综述,为临床研究提供参考.“,”Preeclampsia is caused by the dysfunction of placental trophoblast infiltration.The trophoblast immersed in endometrial layer shallow (only up to decidua layer),concurrently resulted in uterine vascular remodeling disorder,and cause placental tissue ischemia,hypoxia,and a series of clinical manifestations of preeclampsia.Rho is a guanosine triphosphate-binding protein whose downstream molecule is Rho-associated coiled-coil forming protein kinase (Rock).Recent studies suggest that Rho/Rock signaling pathway,by regulating the polymerization state of intracellular microfilament skeleton,affects the behavior and function of cells,such as cell adhesion,migration,cell contraction,infiltration and transformation of cancer cells,etc.Thus is involved in the pathogenesis of many diseases.This article summarized the progress of research in the influence of trophoblast infiltration capacity,activation,regulation and the relationship with pregnancy of Rho/Rock signaling pathway,to provide reference for clinical research.