于ＳＤ怀孕大鼠的致畸敏感期（怀孕６～１５ｄ）抗生素８９—０７２０、４０和８０ｍｇ／（ｋｇ·ｄ）ｉｖ连续１０ｄ，实验结果表明母鼠毒性症状出现在８０和４０ｍｇ组，主要表现为母鼠在给药的１～４ｄ（怀孕的６～９ｄ）其平均体重增长低于对照组（Ｐ＜０。０５）且８０ｍｇ组有１只母鼠死亡，７只母鼠呼吸急促，步态异常。但各剂量组均未见有胎仔生长迟缓，外形异常，内脏组织及骨骼检查变异等症状。因此抗生素８９－０７是不具有发育毒性的药物。 Antibiotics 89-0720, 40 and 80 mg / (kg · d) iv were administered to SD pregnant rats for the first 10 days in the teratogenic and sensitive period (6 ~ 15 days of pregnancy). The results showed that the virulent symptoms appeared in the 80 and 40 mg groups The average body weight gain of female rats from 1 day to 4 days after dosing (6 ~ 9 d of pregnancy) was lower than that of the control group (P <0.05). One female died in the 80 mg group, Abnormal state. However, none of the dose groups showed any symptoms of fetal growth retardation, abnormal appearance, visceral tissue and skeletal variation. Therefore antibiotic 89-07 is a non-developmental drug.