众所周知,淋巴管异常可导致如淋巴水肿和肿瘤转移等严重疾病。然而,直到淋巴内皮细胞特异性标志物的相继发现后,对淋巴管生成的相关研究才得以蓬勃开展起来。本文着重阐述了近年来在淋巴管生成的调控因子和淋巴管生成的靶向治疗的研究领域取得的新进展。 It is well-known that abnormal lymphatic vessels can lead to serious diseases such as lymphedema and tumor metastasis. However, until the discovery of lymphatic endothelial cell-specific markers, the relevant research on lymphangiogenesis has been vigorously carried out. This article highlights the recent advances in the field of targeted therapy of lymphangiogenesis regulators and lymphangiogenesis.