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本研究检测了１４８５例良恶性肝病患者血清ＡＦＰ及其变异体（ＡＦＰ－ｖ）、γ－谷氨酰转肽酶同工酶（ＧＧＴ）和α１抗胰蛋白酶（ＡＡＴ）浓度。４７４例肝癌患者的上述四项标志物水平显著高于１０１１例非癌肝病患者。估测到ＡＦＰ、ＡＦＰ－ｖ、ＧＧＴ和ＡＡＴ的诊断准确度分别为０．８７３、０．８７１、０．９４８和０．９３８。诊断的特异性分别达到０．９５６、０．９９９、０．９９９和０．９９８；同时相应的灵敏度分别为０．６９６、０．５９９、０．８４０和０．８１０。ＧＧＴ和ＡＡＴ是检测ＡＦＰ阴性（＜２０μｇ／Ｌ）肝癌最有效的标志物，其阳性检出率高达９０％；而ＡＦＰ－ｖ是鉴别ＡＦＰ低水平异常升高的（在２０～４００μｇ／Ｌ）肝癌和非癌肝病患者的最佳指标。本研究结果充分证实联合检测多项肿瘤标志物对肝癌具有重要的诊断价值。
This study examined the serum AFP and its variants (AFP-v), γ-glutamyl transpeptidase isoenzyme (GGT) and α1 antitrypsin (AAT) concentrations in 1485 patients with benign and malignant liver disease. The above four markers were significantly higher in 474 patients with liver cancer than in 1011 patients with non-cancer liver disease. The diagnostic accuracy of AFP, AFP-v, GGT, and AAT was estimated to be 0.873, 0.871, 0.948, and 0.938, respectively. The specificity of the diagnosis was 0.956, 0.999, 0.999, and 0.998, respectively; the corresponding sensitivities were 0.696, 0.599, 0.840, and 0.810, respectively. GGT and AAT are the most effective markers for detecting AFP-negative (<20μg/L) liver cancer, and their positive detection rate is as high as 90%. AFP-v is used to identify abnormally high levels of AFP elevation (at 20 to 400 μg/L). The best indicator of liver cancer and non-cancerous liver disease. The results of this study fully confirmed that the combined detection of multiple tumor markers has important diagnostic value for liver cancer.