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地苦胆胶囊是贵州省老年医学研究所根据苗族验方研制的一种民族药物.临床用于咽喉肿痛,脘腹热痛,泄泻,痢疾.为了对其临床应用的安全性作出评价,本文作了其小鼠经口服急性毒性实验,现报告如下.1 材料1.1 药物:地苦胆胶囊由本所研制并提供,胶囊内容物为黄褐色粉末,味苦,批号940620,每g药粉相当于原生药4g,临用时用蒸馏水配制成每ml含药粉0.25g的混悬液.1.2 动物:昆明种小鼠,18g~20g,雌雄各半,雌者无孕,由贵州省药品检验所实验动物室提供.2 方法与结果2.1 预试:取健康小鼠20只,
Diqi Capsule is a kind of national medicine developed by Guizhou Institute of Geriatrics according to Miao nationality prescription. Clinically used for sore throat, abdominal pain, diarrhea, dysentery. In order to evaluate the safety of clinical application, this article makes The oral acute toxicity test of the mice was reported as follows.1. Material 1.1 Drugs: The DDB was developed and provided by the Institute. The contents of the capsules were yellow-brown powder, bitter taste, lot number 940620, and each powder was equivalent to 4g of the original drug. , Prepared with distilled water when formulated into a suspension containing 0.25g of powdered powder per ml. 1.2 Animals: Kunming mice, 18g to 20g, male and female, females were not pregnant, provided by the Experimental Animal Room of the Guizhou Institute for Drug Control. 2 Methods and Results 2.1 Pretest: Take 20 healthy mice