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Crohn氏病(CD)和溃疡性结肠炎(UC)是病因不明的慢性、节段性肠道病变,统称为炎症性肠病(IBD).遗传、肠内上皮功能异常、感染及炎症反应调节的改变等各种因素在其发病过程中都起着重要作用.在溃疡性结肠炎中,循环可溶性L-选择蛋白(sL-选择蛋白)浓度与疾病活动呈正相关,而CD则不然.L-选择蛋白的这种差异可能是因L-选择蛋白配体CD_(34)的疾病特异性调节所致.本文介绍不同疾病活动程度UC或CD患者受累肠组织CD_(34)表达与血清sL-选择蛋白水平的关系.
Crohn’s disease (CD) and ulcerative colitis (UC) are chronic, segmental intestinal lesions of unknown etiology collectively referred to as inflammatory bowel disease (IBD) .General, intestinal epithelial dysfunction, infection, and inflammatory response modulation Changes in the pathogenesis of various factors play an important role in the pathogenesis of ulcerative colitis, circulating soluble L-selectin (sL-selectin) concentration and disease activity was positively correlated, while the CD is not the same.L- This difference in selectin proteins may be due to the disease-specific regulation of the L-selectin ligand CD 34.This article describes the expression of CD34 in intestinal mucosa of patients with UC or CD activity and serum sL-selection Protein level of the relationship.