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目的通过测定３２例脑出血昏迷患者血清、胃液中胃泌素（ＧＡＳ）含量的动态变化，探讨脑出血对胃肠动力的影响及其临床意义。方法采用放免法动态法测定。结果急性脑出血后昏迷患者血清、胃液ＧＡＳ含量第１周显著高于正常对照组，第一个２４小时略高于正常水平，第二个２４小时达高峰，第５天后逐渐下降．第４周接近正常水平：急性脑出血患者ＧＣＳ评分越低，血液、胃液ＧＡＳ含量越高，患者呕吐频率、胃液潜血阳性率、死亡率越高；不同部位脑出血ＧＡＳ含量经ＬＳＤ组间比较无统计学意义。结论急性脑出血昏迷患者存在ＧＡＳ分泌异常。ＧＡＳ作为体内重要的脑－肠肽激素、中枢和外周神经系统强有力的递质，ＧＡＳ参与急性脑出血后继发性病理、生理过程，动态测定急性脑出血后昏迷患者血清、胃液ＧＡＳ含量，对临床观察与判断病情严重程度及探讨脑出血对胃肠动力的影响和选择营养护理提供参考依据。
Objective To determine the dynamic changes of gastrin (GAS) in serum and gastric juice of 32 patients with cerebral hemorrhage coma and to explore the effect of cerebral hemorrhage on gastrointestinal motility and its clinical significance. Method using radioactive method of dynamic determination. Results The levels of GAS in serum and gastric juice in patients with coma after acute intracerebral hemorrhage were significantly higher than those in the normal control group in the first week. The first 24 hours was slightly higher than the normal level, the second 24 hours peaked and decreased gradually after the fifth day. The fourth week was close to the normal level: the lower the GCS score in patients with acute cerebral hemorrhage, the higher the GAS content in blood and gastric juice, the higher the frequency of vomiting, the positive rate of gastric occult blood, the higher the mortality rate; Statistical significance. Conclusion There is abnormal GAS secretion in patients with coma of acute cerebral hemorrhage. GAS is a powerful neurotransmitter of brain-gut peptide, central nervous system and peripheral nervous system in vivo. GAS is involved in secondary pathological and physiological processes after acute cerebral hemorrhage. GAS content in serum and gastric juice of patients with unconsciousness after acute cerebral hemorrhage Clinical observation and judgment of the severity of the disease and to explore the impact of cerebral hemorrhage on gastrointestinal motility and selection of nutritional care provide a reference.